Prabha Ranganathan, MD, MS

Prabha Ranganathan MD MS

Professor of Medicine

Clinical interests

Treatment of rheumatic disease with a focus on rheumatoid arthritis

Research interests

My clinical research interests are in the areas of pharmacogenetics, outcomes research, and the effects of vitamin D in rheumatoid arthritis (RA). We have established that polymorphisms in methotrexate transporter and folate pathway genes are associated with methotrexate toxicity in patients with RA. The ultimate goal of my research in pharmacogenetics is to help individualize treatments for patients with RA by defining genetic profiles which would predict therapeutic outcomes and avoid toxicities. I am involved in outcomes research in RA to identify adverse outcomes, particularly the risk of infections and malignancies, in patients with RA treated with the newer biologic medications versus traditional disease-modifying agents. We have reported on the risk of herpes zoster, Staphylococcal sepsis, hospitalization for infection, non-melanoma skin cancer and head and neck cancer, in patients with RA treated with these agents. I am also interested in the immune modulatory effects of vitamin D in RA.

Selected publications

  1. Ranganathan P, Culverhouse R, Marsh S, Ahluwalia R, Shannon WD, Eisen S, McLeod HL. Single nucleotide polymorphism profiling across the methotrexate pathway in normal subjects and patients with rheumatoid arthritis. Pharmacogenomics 2004;5(5):559-569. PMID: 15212592
  2. Ranganathan P, Culverhouse R, Marsh S, Mody A, Scott-Horton T, Brasington R, Joseph A, Reddy V, Eisen S, McLeod HL. Methotrexate pathway gene polymorphisms and their effects on methotrexate toxicity in Caucasian and African American patients with rheumatoid arthritis. Journal of Rheumatology 2008; 35: 572-9. PMID: 18381794
  3. McDonald JR, Zeringue AL, Caplan L, Ranganathan P, Xian H, Burroughs TE, Fraser VJ, Cunningham F, Eisen SA. Herpes zoster risk factors in a national cohort of veterans with rheumatoid arthritis. Clinical Infectious Diseases 2009;48(10):1364-71. PMID: 19368499
  4. Lane MA, McDonald JR, Zeringue AL, Caplan L, Curtis JR, Ranganathan P, Eisen SA. TNF-α antagonist use and risk of hospitalization for infection in a national cohort of veterans with rheumatoid arthritis. Medicine (Baltimore). 2011 Mar; 90(2):139-45. PMID: 21358439
  5. Amari W, Zeringue AL, McDonald JR, Caplan L, Eisen SA, Ranganathan P. Risk of Non- Melanoma Skin Cancer in a National Cohort of Veterans with Rheumatoid Arthritis. Rheumatology (Oxford). 2011 Mar 16. [Epub ahead of print] PMID: 21415022
  6. Ranganathan P, Khalatbari S, Yalavarthi S, Marder W, Brook R, Kaplan MJ. Vitamin D Deficiency, Interleukin 17, and Vascular Function in Rheumatoid Arthritis. J Rheumatol. 2013 Jul 1. [Epub ahead of print] PMID: 23818717
  7. Sams M, Olsen MA, Joshi R, Ranganathan P. Staphylococcus aureus sepsis in rheumatoid arthritis. Rheumatol Int. 2015 Mar 11. [Epub ahead of print] PMID: 25758228
  8. Phillips C, Zeringue AL, McDonald JR, Eisen SA, Ranganathan P. Tumor Necrosis Factor Inhibition and Head and Neck Cancer Recurrence and Death in Rheumatoid Arthritis. PLoS One. 2015 Nov 23;10(11):e0143286. PMID: 26599370
  9. Selected reviews and book chapters:
  10. P Ranganathan, S Eisen, WM Yokoyama, HL McLeod. Will pharmacogenetics allow better prediction of methotrexate toxicity and efficacy in patients with rheumatoid arthritis? Ann Rheum Dis 2003;62:4-9. PMID: 12480661
  11. Ranganathan P, McLeod HL. Methotrexate pharmacogenetics: the first step toward individualized therapy in rheumatoid arthritis. Arthritis and Rheumatism 2006; 54(5):1366-77. PMID: 16645965
  12. Ranganathan P. Genetics of Systemic Bone Loss in Rheumatoid Arthritis: Role of Vitamin D Receptor (VDR) Polymorphisms. Rheumatology (Oxford). 2009;48(4):342-6. PMID: 19151030
  13. Davila L, Ranganathan P: Pharmacogenetics: Impact on Therapeutics for Rheumatic Disease. Nature Reviews Rheumatology 2011, 7(9):537-50. PMID:21826093
  14. Park HJ, Ranganathan P: TNF-alpha antagonism and cancer risk in rheumatoid arthritis: Is continued vigilance warranted? Discov Med. 2012 Mar;13(70):229-34. PMID: 22463799
  15. Sen D, Ranganathan P: Vitamin D in rheumatoid arthritis: panacea or placebo? Discov Med 14(78):311-319, 2012. PMID: 23200062
  16. Sen D, Paul JR, Ranganathan P: Pharmacogenetics in Rheumatoid Arthritis. Methods in Molecular Biology, Pharmacogenomics in Drug Discovery and Development, Q Yan (ed); 2014;1175:625-60. doi: 10.1007/978-1-4939-0956-8_16. PMID: 25150878
  17. Paul JR, Sen D, Ranganathan P: Rheumatoid Arthritis. Handbook of Pharmacogenomics and Stratified Medicine [Hardcover] Padmanabhan (ed); Academic Press; Publication Date: May 15, 2014 | ISBN-10: 0123868823 | ISBN-13: 978-0123868824 | Edition: 1
  18. Ranganathan P: Rheumatoid arthritis: Biomarkers of response to TNF inhibition in RA. Nat Rev Rheumatol. 2015 Jun 16. doi: 10.1038/nrrheum.2015.83.