Chyi Hsieh, MD

Chyi Hsieh MD

Assistant Professor of Medicine Alan A. and Edith L. Wolff Professor of Rheumatology

Research and publications

  1. Lio, C.W., Dodson, L.F., Deppong, C.M., Hsieh, C.S., and J.M. Green.  CD28 facilitates the generation of Foxp3– cytokine responsive regulatory T cell precursors.  J. Immunol.  2010;  184:6007-6013.
  2. Kreisel D., Richardson S.B., Li W., Lin X., Kornfeld C.G., Sugimoto S., Hsieh C.S., Gelman A.E., and A.S. Krupnick.  Cutting edge: MHC class II expression by pulmonary nonhematopoietic cells plays a critical role in controlling local inflammatory responses.  J. Immunol.  2010:  185:3809-13.
  3. Albring, J.C., Sandau, M.M., Rapaport, A.S., Edelson, B.T., Satpathy, A., Mashayekhi, M., Lathrop, S.K., Hsieh, C.S., Stelljes, M., Colonna, M., Murphy, T.L., and K.M. Murphy.  Targeting of B and T lymphocyte associated (BTLA) prevents graft-versus-host disease without global immunosuppression.  J. Exp. Med.  2010:  207:2551-9.
  4. Lathrop, S.K., Bloom, S.M., Rao, S.M., Nutsch, K., Lio, C.-W., Santacruz, N., Peterson, D.A., Stappenbeck, T.S., and C.S. Hsieh.  Peripheral education of the immune system by colonic commensal microbiota.  Nature  2011:  478:250-4.
  5. Porembka, M.R., Mitchem, J.B,. Belt, B.A., Hsieh, C.S., Lee, H.M., Herndon, J., Gillanders, W.E., Linehan, D.C., and P. Goedegebuure. Pancreatic adenocarcinoma induces bone marrow mobilization of myeloid-derived suppressor cells which promote primary tumor growth.  Cancer Immunol. Immunother.  2012: 61:1373-85.
  6. Lee, H.M., Bautista, J.L., Scott-Browne, J., Mohan, J.F., and C.S. Hsieh. Tuning of thymic regulatory T cell selection to the self-reactive peripheral immune response.  Immunity 2012:  37:475-86.
  7. Piccio, L., Cantoni, C., Henderson, J.G., Hawiger, D., Ramsbottom, M., Mikesell, R., Ryu, J., Hsieh, C.S., Cremasco, V., Haynes, W., Dong, L.Q., Chan, L., Galimberti, D., and A.H. Cross.  Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis.  Eur. J. Immunol.  2013:  43:2089-100.
  8. Deppong, C.M., Bricker, T.L., Rannals, B.D., Van Rooijen, N., Hsieh, C.S., & Green, J.M. (2013).  CTLA4Ig inhibits effector T cells through regulatory T cells and TGF-β.  Journal of Immunology, 191, 3082-9.
  9. Lo, W.L., Solomon, B.D., Donermeyer, D.L., Hsieh, C.S., & Allen, P.M. (2014).  T cell immunodominance is dictated by the positively selecting self-peptide.  Elife, 3:e01457. PMCID: PMC3885792
  10. Ni, P.P., Solomon, B., Hsieh, C.S., Allen, P.M., & Morris, G.P. (2014).  The ability to rearrange dual TCRs enhances positive selection, leading to increased Allo- and Autoreactive T cell repertoires.  J. Immunol. 193:1778-86.  PMCID:  PMC4119549
  11. Perry, J.S.A., Lio, C.W.J.,Kau, A.L., Nutsch, K., Yang, Z., Gordon, J.I., Murphy, K.M., & Hsieh, C.S.  Distinct Contributions of Aire and Antigen-Presenting-Cell Subsets to the Generation of Self-Tolerance in the Thymus.  Immunity, 2014:  41:414-26.  PMCID: PMC4175925
  12. Kau AL, Planer JD, Liu J, Rao S, Yatsunenko T, Trehan I, Manary MJ, Liu TC, Stappenbeck TS, Maleta KM, Ashorn P, Dewey KG, Houpt ER, Hsieh CS, Gordon JI (2015)  Functional characterization of IgA-targeted bacterial taxa from undernourished Malawian children that produce diet-dependent enteropathy.  Sci. Transl. Med.  7, 276ra24.  PMCID: PMC4423598