Minji Byun, PhD

Minji Byun PhD

Assistant Professor of Medicine

Research interests

Only a small proportion of individuals infected with the same microbe go on to develop clinical disease. My laboratory is interested in deciphering the genetic and immunological basis of this phenotypic variability by studying patients with severe infectious diseases or autoimmune diseases triggered by common microbes.

Publications

  1. Byun M, Ma CS, Akcay A, Pedergnana V, Palendira U, Myoung J, Avery DT, Liu Y, Abhyankar A, Lorenzo L, Schmidt M, Lim HK, Cassar O, Migaud M, Rozenberg F, Canpolat N, Aydogan G, Fleckenstein B, Bustamante M, Picard C, Gessain A, Jouanguy E, Cesarman E, Olivier M, Gros P, Abel L, Croft M, Tangye SG, Casanova JL. “Inherited human OX40 deficiency underlying classic Kaposi sarcoma of childhood”, Journal of Experimental Medicine. 2013 Aug 26;210(9):1743-59. doi: 10.1084/jem.20130592. #Corresponding author.
  2. Bolze A, Mahlaoui N, Byun M, Turner B, Trede N, Ellis SR, Abhyankar A, Itan Y, Patin E, Brebner S, Sackstein P, Puel A, Picard C, Abel L, Quintana-Murci L, Faust SN, Williams AP, Baretto R, Duddridge M, Kini U, Pollard AJ, Gaud C, Frange P, Orbach D, Emile JF, Stephan JL, Sorensen R, Plebani A, Hammarstrom L, Conley ME, Selleri L, Casanova JL. 2013. “Ribosomal Protein SA Haploinsufficiency in Humans with Isolated Congenital Asplenia”, Science. 340(6135):976-8.
  3. Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanonic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL. 2012. “Mycobacterial Disease and Impaired IFN-γ Immunity in Humans with Inherited ISG15 Deficiency”, Science. 337(6102):1648-8.
  4. Pedergnana V, Gessain A, Tortevoye P, Byun M, Bacq-Daian D, Boland A, Casanova JL, Abel L, Plancoulaine S. 2012. “A major locus on chromosome 3p22 conferring predisposition to human herpesvirus 8 infection”, European Journal of Human Genetics. doi:10.1038/ejhg.2011.260.
  5. Bolze A, Abhyankar A, Grant AV, Patel B, Yadav R, Byun M, Caillez D, Emile JF, Pastor-Anglada M, Abel L, Puel A, Govindarajan R, de Pontual L, Casanova JL. 2012. “A mild form of SLC29A3 disorder: a frameshift deletion leads to the paradoxical translation of an otherwise noncoding mRNA splice variant”, PLoS One. 7(1):e29708.
  6. Leroy S, Moshous D, Cassar O, Reguerre Y, Byun M, Pedergnana V, Canioni D, Gessain A, Oksenhendler E, Fieschi C, Mahlaoui N, Rivière JP, Herbigneaux RM, Muszlak M, Arnaud JP, Fischer A, Picard C, Blanche S, Plancoulaine S, Casanova JL. 2012. “Multicentric Castleman disease in an HHV-8-infected child born to consanguineous parents with systematic review”, Pediatrics. 129(1):e199-203.
  7. Bolze A, Byun M*, McDonald D*, Morgan NV*, Abhyankar A*, Premkumar L, Puel A, Bacon CM, Rieux-Laucat F, Pang K, Britland A, Abel L, Cant A, Maher ER, Riedl SJ, Hambleton S, Casanova JL. 2010. “Whole-exome-sequencing-based discovery of human FADD deficiency”, American Journal of Human Genetics. 87(6):873-81. *Equal contributors.
  8. Byun M#, Abhyankar A, Lelarge V, Plancoulaine S, Palanduz A, Telhan L, Boisson B, Picard C, Dewell S, Zhao C, Jouanguy E, Feske S, Abel L, Casanova JL#. 2010. “Whole-exome sequencing-based discovery of STIM1 deficiency in a child with fatal classic Kaposi sarcoma”, Journal of Experimental Medicine. 207(11):2307-12. #Corresponding authors.
  9. Byun M, Verweij MC, Pickup DJ, Wiertz EJ, Hansen TH, Yokoyama WM. 2009. “Two mechanistically distinct immune evasion proteins of cowpox virus combine to avoid antiviral CD8 T cells”, Cell Host & Microbe. 6(5):422-32. (Cover article)