Xiaobo Wu, MD
The complement system is an important branch of innate immune response against foreign microbes. The loss of an adequate regulation of complement activation also leads to the uncontrolled innate immune response to the self-antigens and eventually results in a variety of tissue injuries. The overall goal of our studies is to understand the role of complement system in the physiological condition as well as in the autoimmune disorders and infectious diseases. We have established that the complement alternative pathway homeostasis depends upon the adequate regulation of complement activation by a membrane regulatory protein Crry. Due to the significant conservation in molecules and functions of human and mouse complement systems, we are using the genetically modified mouse models to study the molecular mechanisms of complement mediated-diseases or develop strategies to keep complement activation at an adequate level.