Clinical Studies

Washington University clinical rheumatology faculty are actively engaged in research projects on the leading edge of diagnosis and treatment.  The table below presents research projects that are active or in preparation as of January, 2016.  Rheumatology fellows are welcome to participate to gain experience with clinical trial protocol structure and implementation.


Current Clinical Research in the Washington University Division of Rheumatology
Name Funding Source/ Protocol ID WU Investigators Activity Status Description
CASTLE Kypha, Inc Dr. Kim Enrolling Single-center pilot study evaluating the relationship between blood iC3b and SLEDAI2K Responder Index-50 disease activity measurements in SLE patients
ADDRESS-II Merck Serono Drs. Kim, Brasington, Sen Enrolling Phase IIb, multicenter, randomized, double-blind, placebo-controlled, multidose, 52-week study to evaluate efficacy and safety of atacicept in SLE
CALIBATE ITN/NIH Drs. Kim, Li, Miner, Sen Enrolling Phase II, multicenter, prospective, randomized, open-label, 200-week study to evaluate the safety and efficacy of rituximab + cyclophosphamide followed by belimumab in individuals with active SLE nephritis
SPIRIT 1IF-MC-RHBE Drs. Parks, Gonzalez-Mayda Enrolling Multicenter, randomized, double-blind, placebo-controlled 24-week study followed by long-term evaluation of efficacy & safety of Ixekizumab (LY2439821) in biologic disease-modifying antirheumatic drug-experienced patients with active psoriatic arthritis
SABLE Dr. Brasington Enrolling 5-year prospective observational registry to assess adverse events and effectiveness in adults with active, autoantibody-positive SLE treated with or without BENLYSTA™ (belimumab)
SLEEPS Pilot Study Drs. Kim, Chu, Thekkemuriyil Enrolling A prospective study evaluating relationships among patient reported sleep patterns, electronically monitored sleep quality, SLE activity, and selected sleep modifying variables
NIH / EMR_700461-023 Dr. Kim Enrolling Phase IIb, multi-center, randomized, double-blind, placebo-controlled, multidose, 24-week study to evaluate efficacy & safety of atacicept in SLE patients
HGS1006-C1112 Dr. Parks Enrolling Phase 3/4, multi-center, randomized, double-blind, placebo-controlled, 52-week study to evaluate efficacy & safety of Belimumab (HGS1006) in adult African Americans with SLE
Pilot Study Dr. Brasington In Preparation Prospective open label study of acthar subcu gel injection in patients with active anterior uveitis not controlled with or intolerant of topical or systemic corticosteroids
ChemoCentryx Dr. Parks In Preparation Randomized, double-blind, placebo-controlled, dose assessment Phase 2 study to evaluate safety & efficacy of CCX168 in patients with ANCA-associated vasculitis.
CALIBRATE Dr. Kim In Preparation Rituximab + Cyclophosphamide followed by belimumab to treat SLE nephritis
SPIRIT P2 L1F-MC-RHBE ? In Preparation An investigation of safety and efficacy of Ixekizumab in biologic experienced patients with psoriatic arthritis.
REASON NIH Dr. Parks In Preparation Multi-institutional NIH study in which minimally invasive ultrasound guided synovial biopsies are performed on RA patients with active disease. Tissues and blood will be examined to identify potential biomarkers for therapeutic response.