Clinical Studies
Washington University clinical rheumatology faculty are actively engaged in research projects on the leading edge of diagnosis and treatment. The table below presents research projects that are active or in preparation as of January, 2016. Rheumatology fellows are welcome to participate to gain experience with clinical trial protocol structure and implementation.
Current Clinical Research in the Washington University Division of Rheumatology | ||||
Name | Funding Source/ Protocol ID | WU Investigators | Activity Status | Description |
CASTLE | Kypha, Inc | Dr. Kim | Enrolling | Single-center pilot study evaluating the relationship between blood iC3b and SLEDAI2K Responder Index-50 disease activity measurements in SLE patients |
ADDRESS-II | Merck Serono | Drs. Kim, Brasington, Sen | Enrolling | Phase IIb, multicenter, randomized, double-blind, placebo-controlled, multidose, 52-week study to evaluate efficacy and safety of atacicept in SLE |
CALIBATE | ITN/NIH | Drs. Kim, Li, Miner, Sen | Enrolling | Phase II, multicenter, prospective, randomized, open-label, 200-week study to evaluate the safety and efficacy of rituximab + cyclophosphamide followed by belimumab in individuals with active SLE nephritis |
SPIRIT | 1IF-MC-RHBE | Drs. Parks, Gonzalez-Mayda | Enrolling | Multicenter, randomized, double-blind, placebo-controlled 24-week study followed by long-term evaluation of efficacy & safety of Ixekizumab (LY2439821) in biologic disease-modifying antirheumatic drug-experienced patients with active psoriatic arthritis |
SABLE | Dr. Brasington | Enrolling | 5-year prospective observational registry to assess adverse events and effectiveness in adults with active, autoantibody-positive SLE treated with or without BENLYSTA™ (belimumab) | |
SLEEPS | Pilot Study | Drs. Kim, Chu, Thekkemuriyil | Enrolling | A prospective study evaluating relationships among patient reported sleep patterns, electronically monitored sleep quality, SLE activity, and selected sleep modifying variables |
NIH / EMR_700461-023 | Dr. Kim | Enrolling | Phase IIb, multi-center, randomized, double-blind, placebo-controlled, multidose, 24-week study to evaluate efficacy & safety of atacicept in SLE patients | |
HGS1006-C1112 | Dr. Parks | Enrolling | Phase 3/4, multi-center, randomized, double-blind, placebo-controlled, 52-week study to evaluate efficacy & safety of Belimumab (HGS1006) in adult African Americans with SLE | |
Pilot Study | Dr. Brasington | In Preparation | Prospective open label study of acthar subcu gel injection in patients with active anterior uveitis not controlled with or intolerant of topical or systemic corticosteroids | |
ChemoCentryx | Dr. Parks | In Preparation | Randomized, double-blind, placebo-controlled, dose assessment Phase 2 study to evaluate safety & efficacy of CCX168 in patients with ANCA-associated vasculitis. | |
CALIBRATE | Dr. Kim | In Preparation | Rituximab + Cyclophosphamide followed by belimumab to treat SLE nephritis | |
SPIRIT P2 | L1F-MC-RHBE | ? | In Preparation | An investigation of safety and efficacy of Ixekizumab in biologic experienced patients with psoriatic arthritis. |
REASON | NIH | Dr. Parks | In Preparation | Multi-institutional NIH study in which minimally invasive ultrasound guided synovial biopsies are performed on RA patients with active disease. Tissues and blood will be examined to identify potential biomarkers for therapeutic response. |