Cover submitted (unsuccessful) for paper on a “commensal” cryptosporidium (Immunity 2021). It is intended to represent that the major target of the immune system is due to cryptosporidium (purple ovals attached to ‘Immunity’ in this sea of food and bacteria in the small intestine. 

The Hsieh laboratory is interested in understanding the mechanisms that lead to immune tolerance to both self-antigens involved in autoimmune disease, as well as non-self-antigens from antigens that come from the environment such as commensal bacteria or food. We utilize TCR repertoire analysis and germ-free mice to study T cell tolerance. A better understanding of how the immune system develops tolerance may be relevant for understanding autoimmune disease, food allergy, and inflammatory bowel disease.